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vedolizumab (CAT#: TAB-H75)

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DESCRIPTION CATALOG # SIZE PRICE
Anti-Human ITGA4+ITGB7 Recombinant Antibody (vedolizumab) TAB-H75 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Humanized (from mouse) antibody to Human ITGA4+ITGB7. Vedolizumab (trade name vedolizumab) is a monoclonal antibody for the treatment of ulcerative colitis and Crohn's disease.[1] It binds to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1). Blocking the α4β7 integrin results in gut-selective anti-inflammatory activity. It is marketed under the trade name vedolizumab.
  • Type
  • IgG1 - kappa
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, WB and most other immunological methods.
  • CAS
  • 943609-66-3
  • Trade name
  • vedolizumab
  • Specific Activity
  • ITGA4_ITGB7(integrin alpha4 (CD49d)_beta7, integrin alpha4_beta7, integrin α4β7, lymphocyte Peyer s patch adhesion molecule 1, LPAM-1) [Homo sapiens]
  • Purity
  • Purity >95% by SDS-PAGE.

BACKGROUND

  • Introduction
  • Integrins are transmembrane receptors that are the bridges for cell-cell and cell-extracellular matrix (ECM) interactions. When triggered, integrins in turn trigger chemical pathways to the interior (signal transduction), such as the chemical composition and mechanical status of the ECM, which results in a response (activation of transcription) such as regulation of the cell cycle, cell shape, and/or motility; or new receptors being added to the cell membrane
  • Keywords
  • ITGA4; ITGB7; Integrin α4β7; CD49d/β7

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